CYP3A4 Polyclonal Antibody-BS90368

CYP3A4 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90368-50, BS90368-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P08684

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB IF/ICC

All Applications: WB 1:500 - 1:2000
IF/ICC 1:50 - 1:200

Background: CYP3A, the most abundant p450 enzyme in human liver, is responsible for the metabolism of more than 50% of the clinical test & lt; RTI ID = 0.0 & gt; (cYP3A) genes encode monooxygenases-enzymes which catalyze drug metabolism and the synthesis of cholesterol, steroids and other lipids. CYP3A family members localize in organs that associate with drug disposition, including the liver, gastrointestinal tract and kidney. The CYP3A cluster maps to gene locus 7q22.1 and consists of four genes (CYP3A4, CYP3A5, CYP3A7 and CYP3A43) and two pseudogenes ( CYP3A4 is abundant in the endoplasmic reticulum of liver cells and upper intestinal enterocytes. CYP3A4 expression is isducible by glucocorticoids pharmacological agents.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunofluorescence analysis of HeLa cells using CYP3A4 antibody at dilution of 1:100 (40x lens).

Bioworld Molecular Weight: ~ 57 kDa

Specificity: CYP3A4 polyclonal antibody detects endogenous levels of CYP3A4 protein.

Alternative Name: CYP3A4; CP33; CP34; CYP3A; CYP3A3; CYPIIIA3; CYPIIIA4; HLP; NF-25; P450C3; P450PCN1

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 244-503 of human CYP3A4 (NP_059488.2).

Conjugate: Unconjugated

Modification: Unmodified