Cytokeratin 15 (T12) Polyclonal Antibody-BS1201

Cytokeratin 15 (T12) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS1201-50, BS1201-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P19012

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC

All Applications: IHC: 1:50~1:200

Background: Cytokeratin 15 (CK15, K15, K1CO, keratin15, type I cytoskeletal 15) is an intermediate filament (IF) type I protein that is responsible for the mechanical integrity of epithelial cells. Keratin family members are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains, and are clustered in a region on chromosome 17q21.2. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceus. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of Cytokeratin 15 (T12) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Bioworld Molecular Weight: ~ 49 kDa

Specificity: Cytokeratin 15 (T12) polyclonal antibody detects endogenous levels of Cytokeratin 15 protein.

Alternative Name: Keratin, type I cytoskeletal 15; Cytokeratin-15, Short name=CK-15; Keratin-15; Short name=K15; KRT15; KRTB; Keratin 15; CK15; CK 15; Keratin15

Immunogen: Synthetic peptide, corresponding to the N-terminus of Human Cytokeratin 15.

Conjugate: Unconjugated

Modification: Unmodified