Product Description

Dab1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES2139-50, ES2139-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IF, ELISA

Alternate Names: DAB1, Disabled homolog 1

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human Dab1. AA range:199-248

Isotype: IgG

Target: Dab1

Specificity: Dab1 Polyclonal Antibody detects endogenous levels of Dab1 protein.

Dilution: Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Mainly expressed in brain,

Observed Band (KD): 60kD

Fields: Spinocerebellar ataxia

Function: Domain: The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins
Function: Adapter molecule functioning in neural development. May regulate SIAH1 activity
PTM: Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons (By similarity). Also phosphorylated on Ser-524 independently of reelin signaling
Similarity: Contains 1 PID domain
Subunit: Associates with the SH2 domains of SRC, FYN and ABL. Interacts with DAB2IP and SIAH1 (By similarity). Interacts with LRP1

Subcellular Location: nucleolus, microtubule organizing center, cytosol, brush border, postsynaptic density, membrane, neuron projection, neuronal cell body, intracellular membrane-bounded organelle, apical part of cell, perinuclear region of cytoplasm,

Storage and Stability: -20°C/1 year

Gene Name: DAB1

Protein Name: Disabled homolog 1

Mouse Gene ID: 13131

Mouse SwissProt Number: P97318

Rat Gene ID: 266729

Rat SwissProt Number: Q8CJH2

Research Use Only