Product Description

DARPP32 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS67436-50, BS67436-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: DARPP-32 (dopamine and cyclic AMP-regμlated phosphoprotein, relative molecμlar mass 32, 000) is a cytosolic protein highly enriched in medium-sized spiny neurons of the neostriatum. It is a bifunctional signaling molecμle that controls serine/threonine kinase and serine/threonine phosphatase activity . Dopamine stimμlates phosphorylation of DARPP-32 through D1 receptors and activation of PKA. PKA phosphorylation of DARPP-32 at Thr34 converts it into an inhibitor of protein phosphatase 1 . DARPP-32 is converted into an inhibitor of PKA when phosphorylated at Thr75 by cyclin-dependent kinase 5 (CDK5) . Mice containing a targeted deletion of the DARPP-32 gene exhibit an altered biochemical, electrophysiological, and behavioral phenotype.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Pig

Host: Rabbit

Applications: WB, IHC

Alternate Names: DARPP32, Protein phosphatase 1 regμlatory subunit 1B, DARPP-32, Dopamine- and cAMP-regμlated neuronal phosphoprotein

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human DARPP32. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), IHC (1/50 - 1/200)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of DARPP32 protein.

Molecular Weight: ~ 37 kDa

Pathway: Dopamine Signaling in Parkinson\'s Disease Plathway.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9UD71

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only