DAXX Monoclonal Antibody - BT-MCA4452

DAXX Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4452-50, BT-MCA4452-100

Citations, Manuals and MSDS Available upon request.

Background: DAXX (death-domain associated protein), it is a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.

Research Areas: Cell Biology

Target Protein: DAXX

Applications: WB, ICC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 7A11

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: DAXX

Immunogen: Purified recombinant fragment of human DAXX expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 81kDa

UniProt Accession: Q9UER7

Synonyms: DAP6, EAP1, BING2

GeneID: 1616

Research Use Only