Product Description

DBP Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES2149-50, ES2149-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011],

Reactivity: Human, Monkey

Host: Rabbit

Applications: WB, ELISA

Alternate Names: GC, Vitamin D-binding protein, DBP, VDB, Gc-globulin, Group-specific component

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from DBP. at AA range: 90-170

Isotype: IgG

Target: DBP

Specificity: DBP Polyclonal Antibody detects endogenous levels of DBP protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in the liver, Found in plasma, ascites, cerebrospinal fluid and urine,

Observed Band (KD): 55kD

Function: Function: Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes
polymorphism: Over 80 variants of human DBP have been identified. The three most common alleles are called GC*1F, GC*1S, and GC*2. The sequence shown is that of the GC*2 allele
Similarity: Belongs to the ALB/AFP/VDB family
Similarity: Contains 3 albumin domains

Subcellular Location: Secreted

Storage and Stability: -20°C/1 year

Gene Name: GC

Protein Name: Vitamin D-binding protein

Mouse SwissProt Number: P21614

Research Use Only