DCX Monoclonal Antibody - BT-MCA3581

DCX Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3581-50, BT-MCA3581-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.

Research Areas: Neuroscience

Target Protein: DCX

Applications: WB, IHC, ICC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 2G5

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: DCX

Immunogen: Purified recombinant fragment of human DCX (AA: 362-411) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 49.3kDa

UniProt Accession: O43602

Synonyms: DC, DBCN, LISX, SCLH, XLIS

GeneID: 1641

Research Use Only