DDR1 Monoclonal Antibody - BT-MCA4214

DDR1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4214-50, BT-MCA4214-100

Citations, Manuals and MSDS Available upon request.

Background: DDR1: discoidin domain receptor tyrosine kinase 1. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.

Research Areas: Neuroscience

Target Protein: DDR1

Reactivity: Human

Clonality: Monoclonal

Clone ID: 2G4E12

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: DDR1

Immunogen: Purified recombinant fragment of DDR1 (aa602-681) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: Q08345

Synonyms: CAK, DDR, NEP, PTK3, RTK6, TRKE, CD167

GeneID: 780

Research Use Only