DDR2 Monoclonal Antibody - BT-MCA3721

DDR2 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3721-50, BT-MCA3721-100

Citations, Manuals and MSDS Available upon request.

Background: DDR2 (discoidin domain receptor family, member 2) is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/ threonine (STK) kinase catalytic domains. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.

Research Areas: Cardiovascular, Neuroscience

Target Protein: DDR2

Applications: IHC, ICC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 3B11E4

Host: Mouse

Isotype: Mouse IgG2a

Full Product Name: DDR2

Immunogen: Purified recombinant fragment of human DDR2 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: Q16832

Synonyms: TKT, MIG20a, NTRKR3, TYRO10

GeneID: 4921

Research Use Only