DefensinAlpha4 Polyclonal Antibody - BT-AP02563

DefensinAlpha4 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP02563-20, BT-AP02563-50, BT-AP02563-100

Citations, Manuals and MSDS Available upon request.

Background: Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. DEFA4 differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. Neutrophil defensin 4 encoded by DEFA4, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production.

Research Areas: Others

Target Protein: DEFA4

Applications: IHC-p, ELISA

Reactivity: Human

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Defensin alpha4 Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 10504

UniProt Accession: Human: P12838

Synonyms: DEFA4; DEF4; Neutrophil defensin 4; Defensin; alpha 4; HNP-4; HP-4

GeneID: Human: 1669

Research Use Only