DERL1 Polyclonal Antibody - BT-AP08449

DERL1 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP08449-20, BT-AP08449-50, BT-AP08449-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimerandapos;s disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Research Areas: Signal transduction

Target Protein: DERL1

Applications: WB, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Derlin-1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q9BUN8; Mouse: Q99J56

Synonyms: Derlin-1;Degradation in endoplasmic reticulum protein 1;DERtrin-1;Der1-like protein 1

GeneID: Human: 79139

Research Use Only