DFFB Monoclonal Antibody - BT-MCA3705

DFFB Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3705-50, BT-MCA3705-100

Citations, Manuals and MSDS Available upon request.

Background: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined.

Research Areas: Cancer, Cell biology, Epigenetics and nuclear signaling, Metabolism

Target Protein: DFFB

Applications: IHC, FCM

Clonality: Monoclonal

Clone ID: 2E6G3

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: DFFB

Immunogen: Purified recombinant fragment of human DFFB (AA: 1-289) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 39.1kDa

UniProt Accession: O76075

Synonyms: CAD, CPAN, DFF2, DFF40, DFF-40

GeneID: 1677

Research Use Only