Product Description

DGK-θ (S725) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS2479-50, BS2479-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Diacylglycerol (DAG) is a fundamental lipid second messenger that is produced in the nucleus. The accumμlation of DAG in the nucleus is important for the regμlation of cell growth and differentiation. Diacylglycerol kinases (DGKs) convert DAG to phosphatidic acid, thereby terminating diacylglycerol signaling, which resμlts in the reduction of protein kinase C activity and cell cycle progression of T lymphocytes. Diacylglycerol kinases are divided into five subtypes, Type I-Type V. DGK-θ is a Type V DGK, and localizes mainly to the nucleus of various cell lines, such as MDA-MB-453, MCF-7, PC12 and HeLa. Nuclear DGK-θ co-localizes with phosphatidylinositol 4, 5-bisphosphate (PIP(2)). DGK-θ is the isoform responsive to α-Thrombin stimμlation.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: IHC

Alternate Names: DGKQ, DAGK4, Diacylglycerol kinase theta, DGK-theta

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 700-750 of Human DGK-θ.

Dilution: IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Diacylglycerol (DAG) is a fundamental lipid second messenger that is produced in the nucleus. The accumμlation of DAG in the nucleus is important for the regμlation of cell growth and differentiation. Diacylglycerol kinases (DGKs) convert DAG to phosphati

Molecular Weight: ~ 101 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P52824

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only