DHRS2 Polyclonal Antibody - BT-AP02603

DHRS2 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP02603-20, BT-AP02603-50, BT-AP02603-100

Citations, Manuals and MSDS Available upon request.

Background: DHRS2 (dehydrogenase/reductase (SDR family) member 2), also known as SDR25C1 or HEP27, is a 258 amino acid protein that localizes to the nucleus and belongs to the short-chain dehydrogenase/reductase (SDR) family. Functioning as an NADPH-dependent dicarbonyl reductase, DHRS2 is thought to inhibit cell replication by either converting cortisone in cortisol, or by catalyzing the oxidation of androgen and estrogen. The gene encoding DHRS2 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder α1-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction.

Research Areas: Others

Target Protein: DHRS2

Applications: WB, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: DHRS2 Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 27439

UniProt Accession: Human: Q13268

Synonyms: DHRS2; Dehydrogenase/reductase SDR family member 2; Dicarbonyl reductase HEP27; Protein D

GeneID: Human: 10202

Research Use Only