Product Description

DHS Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES2171-50, ES2171-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2011],

Reactivity: Human, Rat, Mouse,

Host: Rabbit

Applications: WB, ELISA

Alternate Names: DHPS, DS, Deoxyhypusine synthase, DHS

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human DHPS. AA range:51-100

Isotype: IgG

Target: DHS

Specificity: DHS Polyclonal Antibody detects endogenous levels of DHS protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Blood, Brain, Cervix carcinoma, Lung,

Observed Band (KD): 45kD

Function: Catalytic Activity: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
Cofactor: NAD
Function: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue
Pathway: Protein modification, eIF5A hypusination
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR
Similarity: Belongs to the deoxyhypusine synthase family
Subunit: Homotetramer formed by a dimer of dimers

Subcellular Location: cytoplasm, cytosol,

Storage and Stability: -20°C/1 year

Gene Name: DHPS

Protein Name: Deoxyhypusine synthase

Mouse SwissProt Number: Q3TXU5

Research Use Only