DNA Ligase I Polyclonal Antibody - BT-AP02651

DNA Ligase I Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP02651-20, BT-AP02651-50, BT-AP02651-100

Citations, Manuals and MSDS Available upon request.

Background: LIG1 encodes a member of the ATP-dependent DNA ligase protein family. DNA ligase 1 functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of LIG1 may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants.

Research Areas: Epigenetics and Nuclear Signaling

Target Protein: LIG1

Applications: WB, IHC-p, ELISA

Reactivity: Human

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: DNA Ligase I Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 101736

UniProt Accession: Human: P18858; Mouse: P37913

Synonyms: LIG1; DNA ligase 1; DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1

GeneID: Human: 3978

Research Use Only