Dok-5 Polyclonal Antibody - BT-AP02701

Dok-5 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP02701-20, BT-AP02701-50, BT-AP02701-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by DOK5 (docking protein 5) is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of DOK5 results in multiple transcript variants.

Research Areas: Signal Transduction

Target Protein: DOK5

Applications: WB, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Dok-5 Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 35464

UniProt Accession: Human: Q9P104; Mouse: Q91ZM9

Synonyms: DOK5; C20orf180; Docking protein 5; Downstream of tyrosine kinase 5; Insulin receptor substrate 6; IRS-6; IRS6

GeneID: Human: 55816; Mouse: 76829

Research Use Only