Product Description

DRA Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES4147-50, ES4147-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: SLC26A3, DRA, Chloride anion exchanger, Down-regulated in adenoma, Protein DRA, Solute carrier family 26 member 3

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from the C-terminal region of human DRA.

Isotype: IgG

Target: DRA

Specificity: DRA Polyclonal Antibody detects endogenous levels of DRA protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Colon, Lung, Rectum tumor,

Observed Band (KD): 84kD

Fields: Pancreatic secretion, Mineral absorption

Function: Developmental Stage: Expression is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon
Disease: Defects in SLC26A3 are the cause of congenital chloride diarrhea (CLD) [MIM: 214700]. CLD is a disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature
Function: Chloride/bicarbonate exchanger. Involved in absorbtion of in the colon. Helps mediate electrolyte and fluid absorption
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR
Similarity: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family
Similarity: Contains 1 STAS domain
Subunit: Interacts with PDZK1

Subcellular Location: Apical cell membrane, Multi-pass membrane protein Membrane, Multi-pass membrane protein Localized in sperm membranes Midpiece of sperm tail Colocalizes with CFTR at the midpiece of sperm tail (By similarity)

Storage and Stability: -20°C/1 year

Gene Name: SLC26A3

Protein Name: Chloride anion exchanger

Mouse Gene ID: 13487

Mouse SwissProt Number: Q9WVC8

Rat Gene ID: 114629

Rat SwissProt Number: Q924C9

Research Use Only