Product Description

DUSP19 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES2206-50, ES2206-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: dual specificity phosphatase 19(DUSP19) Homo sapiens Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009],

Reactivity: Human, Monkey

Host: Rabbit

Applications: WB, IF, ELISA

Alternate Names: DUSP19, DUSP17, LMWDSP3, SKRP1, Dual specificity protein phosphatase 19, Dual specificity phosphatase TS-DSP1, Low molecular weight dual specificity phosphatase 3, LMW-DSP3, Protein phosphatase SKRP1, Stress-activated protein kinase pathway

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human DUSP19. AA range:111-160

Isotype: IgG

Target: DUSP19

Specificity: DUSP19 Polyclonal Antibody detects endogenous levels of DUSP19 protein.

Dilution: Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in the heart, lung, liver, and pancreas, The expression level in the pancreas is the highest,

Observed Band (KD): 28kD

Function: Catalytic Activity: A phosphoprotein + H(2)O = a protein + phosphate
Catalytic Activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Function: Has a dual specificity toward Ser/Thr and Tyr-containing proteins
Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily
Similarity: Contains 1 tyrosine-protein phosphatase domain
Tissue Specificity: Expressed in the heart, lung, liver, and pancreas. The expression level in the pancreas is the highest

Storage and Stability: -20°C/1 year

Gene Name: DUSP19

Protein Name: Dual specificity protein phosphatase 19

Mouse SwissProt Number: Q8K4T5

Research Use Only