Dynactin 1 Monoclonal Antibody - BT-MCA0449

Dynactin 1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0449-50, BT-MCA0449-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [

Research Areas: Signal transduction; Neuroscience

Target Protein: DCTN1

Applications: WB, IF, ICC

Reactivity: Human,Mouse,Bovine,Pig

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Dynactin subunit 1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q14203; Mouse: O08788

Synonyms: DCTN1; Dynactin subunit 1; 150 kDa dynein-associated polypeptide; DAP-150; DP-150; p135; p150-glued

GeneID: Human: 1639; Mouse: 13191

Research Use Only