Product Description

Dynein LC 1 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES2209-50, ES2209-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011],

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IHC, IF, ELISA

Alternate Names: DNAL1, C14orf168, Dynein light chain 1, axonemal

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human DNAL1. AA range:121-170

Isotype: IgG

Target: Dynein LC 1

Specificity: Dynein LC 1 Polyclonal Antibody detects endogenous levels of Dynein LC 1 protein.

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Expressed in tissues carrying motile cilia such as respiratory epithelia, ependyma and testis,

Observed Band (KD): 22kD

Fields: Amyotrophic lateral sclerosis, Huntington disease, Pathways of neurodegeneration - multiple diseases

Function: Similarity: Belongs to the dynein light chain LC1-type family
Similarity: Contains 4 LRR (leucine-rich) repeats
Subunit: Interacts with DNAH5
Tissue Specificity: Expressed in tissues carrying motile cilia such as testis

Subcellular Location: Cytoplasm, cytoskeleton, cilium axoneme

Storage and Stability: -20°C/1 year

Gene Name: DNAL1

Protein Name: Dynein light chain 1 axonemal

Mouse Gene ID: 105000

Mouse SwissProt Number: Q05A62

Research Use Only