DYR1A Polyclonal Antibody - BT-AP15347

DYR1A Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP15347-20, BT-AP15347-50, BT-AP15347-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5andapos; UTR or in the 3andapos; co

Research Areas: Microbiology; Neuroscience

Target Protein: DYRK1A

Applications: WB, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q13627; Mouse: Q61214; Rat: Q63470

Synonyms: Dual specificity tyrosine-phosphorylation-regulated kinase 1A;EC 2.7.12.1;Dual specificity YAK1-related kinase;HP86;Protein kinase minibrain homolog;MNBH;hMNB

GeneID: Human: 1859

Research Use Only