E-cadherin Monoclonal Antibody - BT-MCA0453

E-cadherin Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0453-50, BT-MCA0453-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.

Research Areas: Signal transduction; Cancer; Developmental biology

Target Protein: CDH1

Applications: WB, IHC-p, IF, FCM, ELISA

Reactivity: Human,Mouse,Monkey

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Cadherin-1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P12830; Mouse: P09803

Synonyms: CDH1; CDHE; UVO; Cadherin-1; CAM 120; 80; Epithelial cadherin; E-cadherin; Uvomorulin; CD antigen CD324

GeneID: Human: 999; Mouse: 12550

Research Use Only