E2A Monoclonal Antibody - BT-MCA0454

E2A Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0454-50, BT-MCA0454-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1|19), with PBX1), childhood leukemia (t(19|19), with TFPT) and acute leukemia (t(12|19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have bee

Research Areas: Epigenetics and nuclear signaling; Stem cells

Target Protein: TCF3

Applications: WB, FCM, ELISA

Reactivity: Human

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Transcription factor E2-alpha

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P15923; Mouse: P15806

Synonyms: TCF3; BHLHB21; E2A; ITF1; Transcription factor E2-alpha; Class B basic helix-loop-helix protein 21; bHLHb21; Immunoglobulin enhancer-binding factor E12; E47; Immunoglobulin transcription factor 1; Kappa-E2-binding factor; Transcription facto

GeneID: Human: 6929

Research Use Only