E2F1 Monoclonal Antibody - BT-MCA4272

E2F1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4272-50, BT-MCA4272-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.

Research Areas: Epigenetics and Nuclear Signaling

Target Protein: E2F1

Applications: WB, IHC, FCM

Reactivity: Human, Mouse

Clonality: Monoclonal

Clone ID: 8G9

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: E2F1

Immunogen: Purified recombinant fragment of human E2F1 (AA: 69-223) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 46.9kDa

UniProt Accession: Q01094

Synonyms: RBP3, E2F-1, RBAP1, RBBP3

GeneID: 1869

Research Use Only