Product Description

EAAT2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES20771-50, ES20771-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010],

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB

Alternate Names: Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2)

Clonality: Polyclonal

Immunogen: Synthetic Peptide of EAAT2 AA range: 370-420

Isotype: IgG

Target: EAAT2

Specificity: EAAT2 protein(A223) detects endogenous levels of EAAT2

Dilution: WB 1:1000-2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain, Brain cortex, Pancreas,

Observed Band (KD): 62kD

Fields: Synaptic vesicle cycle, Glutamatergic synapse, Amyotrophic lateral sclerosis, Huntington disease

Function: Function: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium
PTM: Glycosylated
Similarity: Belongs to the sodium: dicarboxylate (SDF) symporter (TC 2.A.23) family
Subunit: Homotrimer. Interacts with JUB

Subcellular Location: Cell membrane, Multi-pass membrane protein

Storage and Stability: -20°C/1 year

Gene Name: SLC1A2

Protein Name: Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2)

Mouse SwissProt Number: P43006

Rat SwissProt Number: P31596

Research Use Only