Product Description

EGFR (phospho-Y1173) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4741-50, BS4741-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: EGFR is a receptor tyrosine kinase. Receptor for epidermal growth factor (EGF) and related growth factors including TGF-alpha, amphiregμlin, betacellμlin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. . A single-pass transmembrane tyrosine kinase. Ligand binding to this receptor resμlts in receptor dimerization, autophosphorylation (in trans), activation of various downstream signaling molecμles and lysosomal degradation.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, IHC, IF/ICC, IP

Alternate Names: EGFR, ERBB, ERBB1, HER1, Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylated

Immunogen: KLH-conjugated synthetic phosphopeptide corresponding to residues surrounding Y1173 of human EGFR protein.

Dilution: WB: 1:500-1:1000
IHC: 1:50-1:100
IF/ICC: 1:50-1:100
IP: 1:50-1:100

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: EGFR (phospho-Y1173) polyclonal antibody detects endogenous levels of EGFR protein only when phosphorylated at Tyr1173.

Molecular Weight: ~ 160 kDa

Pathway: ErbB HER Signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P00533

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only