ELOC Polyclonal Antibody - E-AB-19103

ELOC Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-19103-60, E-AB-19103-120, E-AB-19103-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: ELOC

Target Synonym: Elongin C; Transcription Elongation Factor B (SIII); Polypeptide 1 (15kDa; Elongin C); RNA Polymerase II Transcription Factor SIII Subunit C; Transcription Elongation Factor B Polypeptide 1; Transcription Elongation Factor B Subunit 1; Elongin 15 KDa Subunit; SIII P15.

Research Areas: Epigenetics and Nuclear Signaling

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse, Rat

Application: IHC, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q15369

Background: This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified.

Concentration: 0.96 mg/mL

Immunogen: Fusion protein of human ELOC

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: IHC 1:50-1:300, ELISA 1:5000-1:10000

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only