EP300 Monoclonal Antibody - BT-MCA2135

EP300 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2135-50, BT-MCA2135-100

Citations, Manuals and MSDS Available upon request.

Background: EP300: E1A binding protein p300. This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.

Research Areas: Epigenetics and Nuclear Signaling

Target Protein: EP300

Reactivity: Human

Clonality: Monoclonal

Clone ID: 7D8A6

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: EP300

Immunogen: Purified recombinant fragment of EP300 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: Q09472

Synonyms: p300, KAT3B

GeneID: 2033

Research Use Only