EPO Receptor Polyclonal Antibody Sizes: 50μl, 100μl Catalogue Numbers: BS67758-50, BS67758-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: Erythropoiesis is regμlated through the interaction of erythropoietin (Epo) with its receptor, EpoR, a member of the cytokine superfamily of receptors. The human EpoR is a 507 amino acid transmembrane protein that forms homodimers following erythropoietin activation and is related to the interleukin 2 (IL-2) receptor b-chain subunit (IL-2Rb). EpoR and IL-2Rb share 45% amino acid identity within the box 1 and box 2 domains of their cytoplasmic regions while their remaining cytoplasmic sequences are highly divergent. These conserved domains are both required and sufficient for mitogenesis and for coupling ligand binding to the induction of tyrosine phosphorylation. The membrane proximal region is also required for the association of JAK2 with EpoR. The existence of mμltiple cross-linked complexes and differential ligand affinities suggests that EpoR may exist as a mμltireceptor complex. Category: Primary Antibody Reactivity: Human, Mouse, Rat Host: Rabbit Applications: WB, IHC, IF/ICC Alternate Names: Erythropoietin receptor, EPO-R Clonality: Polyclonal Conjugate: Unconjugated Modification: Unmodification Immunogen: Recombinant protein corresponding to human EPO Receptor. The exact sequence is proprietary. Dilution: WB (1/500 - 1/1000), IHC (1/50 - 1/200), IF/ICC (1/50 - 1/200) Purification: The antibody was purified by immunogen affinity chromatography. Specificity: Recognizes endogenous levels of EPO Receptor protein. Molecular Weight: ~ 52 kDa Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. SwissProt: P19235 Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide. Research Use Only