ER Monoclonal Antibody - BT-MCA4284

ER Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4284-50, BT-MCA4284-100

Citations, Manuals and MSDS Available upon request.

Background: ER (estrogen receptor 1) a member of the steroid receptor superfamily, contains highly conserved DNA binding (DBD) and ligand binding domains (LBD). Through its estrogen-independent and estrogen-dependent activation domains (AF-1 and AF-2, respectively), ER regulates transcription by recruiting coactivator proteins and interacting with general transcriptional machinery. Phosphorylation provides an important mechanism to regulate ER activity. ER is phosphorylated on multiple sites. Serines 104, 106, 118 and 167 are located in the amino-terminal transcription activation function domain AF-1, and phosphorylation of these serines plays an important role in regulating ER activity. Ser118 may be the substrate of the transcription regulatory kinase cdK7. Ser167 may be phosphorylated by p90RSK and Akt. Phosphorylation of Ser167 may confer tamoxifen resistance in breast cancer patients.

Research Areas: Others

Target Protein: ER

Applications: WB

Reactivity: Human

Clonality: Monoclonal

Clone ID: 5D4B1

Host: Mouse

Isotype: Mouse IgG2b

Full Product Name: ER

Immunogen: Purified recombinant fragment of ER expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: P03372

Synonyms: ER, ESR, Era, ESRA, NR3A1, DKFZp686N23123, ESR1

GeneID: 2099

Research Use Only