ErbB-3 Monoclonal Antibody - BT-MCA0503

ErbB-3 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0503-50, BT-MCA0503-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the m

Research Areas: Signal transduction; Cancer

Target Protein: ERBB3

Applications: WB, IF, ICC, ELISA

Reactivity: Human

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Receptor tyrosine-protein kinase erbB-3

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P21860; Mouse: Q61526

Synonyms: ERBB3; HER3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3

GeneID: Human: 2065

Research Use Only