Product Description

ErbB-4 / HER4 (phospho-Y1284) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS6360-50, BS6360-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a fμll length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregμlin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: 4ICD, Avian erythroblastic leukemia viral oncogene homolog 4, Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4, E4ICD, EC 2.7.10.1, ErbB4, ERBB4 intracellμlar domain, ERBB4, HER 4, HER4, Mer4, MGC138404, Oncogene ERBB4, P180erbB4, Proto-oncogene-like protein c-ErbB-4, Receptor protein tyrosine kinase erbB 4 precursor, Receptor tyrosine protein kinase erbB 4, s80HER4, Tyrosine kinase type cell surface receptor HER4, Tyrosine kinase-type cell surface receptor HER4, v erb a avi

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human ErbB-4 / HER4 around the phosphorylation site of Tyrosine 1284.

Dilution: WB: 1:500~1:2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-HER4(Y1284) polyclonal antibody detects endogenous levels of HER4 protein only when phosphorylated at Tyr1284.

Molecular Weight: ~ 200 kDa

Pathway: ErbB HER Signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q15303

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only