ERBB2 Monoclonal Antibody - BT-MCA2571

ERBB2 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2571-50, BT-MCA2571-100

Citations, Manuals and MSDS Available upon request.

Background: ERBB2: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian). This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Research Areas: Tags and Cell Markers

Target Protein: ERBB2

Applications: WB, IHC, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 6C2

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: ERBB2

Immunogen: Purified recombinant fragment of human ERBB2(aa750-987) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 180kDa

UniProt Accession: P04626

Synonyms: NEU, HER2, TKR1, CD340, HER-2

GeneID: 2064

Research Use Only