ERCC2 Polyclonal Antibody - BT-AP15452

ERCC2 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP15452-20, BT-AP15452-50, BT-AP15452-100

Citations, Manuals and MSDS Available upon request.

Background: The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research Areas: Epigenetics and nuclear signaling

Target Protein: ERCC2

Applications: WB, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: TFIIH basal transcription factor complex helicase XPD subunit

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P18074; Mouse: O08811

Synonyms: TFIIH basal transcription factor complex helicase XPD subunit;EC 3.6.4.12;Basic transcription factor 2 80 kDa subunit;BTF2 p80;CXPD;DNA excision repair protein ERCC-2;DNA repair protein com

GeneID: Human: 2068

Research Use Only