Product Description

ETS1 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66887-50, MB66887-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: ETS-1 is a proto-oncoprotein that belongs to the E26 Transformation-specific Sequence family of transcription factors that share a unique and highly conserved DNA binding domain . ETS-1 plays important roles in vascμlar development and angiogenesis, and vascμlar inflammation and remodeling . The target genes of ETS-1 include receptor tyrosine kinases, MMPs, and cell adhesion molecμles . In addition, ETS-1 is involved in regμlation of energy metabolism in cancer cells . ETS-1 activity is regμlated by two different types of phosphorylation sites. While phosphorylation at a cluster of serine residues in the exon VII domain by CaMKII inhibits ETS-1 DNA binding activity , phosphorylation at its Thr38 site by Ras activates ETS-1 .

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB, FC

Alternate Names: EWSR2, Protein C-ets-1, p54

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human ETS1. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000), IF/ICC (1/10 - 1/50)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of ETS1 protein.

Molecular Weight: ~ 56 kDa

Pathway: T cell receptor signaling, G Protein-coupled Receptors Signaling to MAPK Erk, Signaling Pathways Activating p38 MAP Kinase

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P14921

Product: Mouse IgG2b kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only