F8 Monoclonal Antibody - BT-MCA2968

F8 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2968-50, BT-MCA2968-100

Citations, Manuals and MSDS Available upon request.

Background: F8: coagulation factor VIII, procoagulant component. This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

Research Areas: Cardiovascular

Target Protein: F8

Reactivity: Human

Clonality: Monoclonal

Clone ID: 5E9B2

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: F8

Immunogen: Purified recombinant fragment of F8 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: P00451

Synonyms: AHF, F8B, F8C, HEMA, FVIII

GeneID: 2157

Research Use Only