Factor VIII Monoclonal Antibody - BT-MCA0524

Factor VIII Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA0524-50, BT-MCA0524-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation| factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

Research Areas: Cardiovascular

Target Protein: F8

Applications: WB, ELISA

Reactivity: Human

Clonality: Monoclonal

Host: Mouse

Isotype: IgG

Full Product Name: Coagulation factor VIII

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P00451; Mouse: Q06194

Synonyms: F8; F8C; Coagulation factor VIII; Antihemophilic factor; AHF; Procoagulant component

GeneID: Human: 2157

Research Use Only