FADD Monoclonal Antibody - BT-MCA2731

FADD Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2731-50, BT-MCA2731-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]

Research Areas: Cell Biology

Target Protein: FADD

Applications: FCM

Clonality: Monoclonal

Clone ID: 5A6A2

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: FADD

Immunogen: Purified recombinant fragment of human FADD (AA: 20-150) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 23.3kDa

UniProt Accession: Q13158

Synonyms: GIG3, MORT1

GeneID: 8772

Research Use Only