FADD Rabbit pAb - A20252

FADD Rabbit pAb

Sizes: 20μL, 100μL

Catalogue Numbers: A20252-20, A20252-100

Citations, Manuals and MSDS Available upon request.

Background: Predicted to enable several functions, including caspase binding activity; death effector domain binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; negative regulation of activation-induced cell death of T cells; and positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation. Acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand; motor neuron apoptotic process; and regulation of programmed cell death. Predicted to be located in several cellular components, including cell body; cytosol; and membrane raft. Predicted to be part of CD95 death-inducing signaling complex and ripoptosome. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog (s) of this gene implicated in leukemia. Orthologous to human FADD (Fas associated via death domain).

Category: Polyclonal Antibodies

Applications: WB, IP, IF-P, ELISA

Cross-reactivity: Human, Mouse, Rat

Protein Weight: 23kDa

Observed Molecular Weight: 28kDa

Immunogen: Recombinant protein (or fragment)

Species: Mouse

GeneID: 14082

SWISS: Q61160

Alternate Names: Mort1/FADD; FADD

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis),  pH 7.3.

Recommended Dilutions: WB, 1:500 - 1:1000 IP, 0.5μg-4μg antibody for 400μg-600μg extracts of whole cells IF-P, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

NCBI Alias: Fadd

Research Use Only