FAS Monoclonal Antibody - BT-MCA2359

FAS Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2359-50, BT-MCA2359-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

Research Areas: Cell Biology

Target Protein: FAS

Applications: WB, FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 4F8D6

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: FAS

Immunogen: Purified recombinant fragment of human FAS expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 37.7kDa

UniProt Accession: P25445

Synonyms: APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6

GeneID: 355

Research Use Only