FER Monoclonal Antibody - BT-MCA4151

FER Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4151-50, BT-MCA4151-100

Citations, Manuals and MSDS Available upon request.

Background: FER (fer tyrosine kinase) is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases, which shares a functional domain and is involved in signaling pathways through receptor tyrosine kinases (RTK) and cytokine receptors. The Fes /Fps family is distinct from c-Src, c-Abl and related nRTKs and was originally distinguished as a homolog to retroviral oncoproteins. In vivo, Fer kinase assembles into homotrimers via conserved coiled-coil domains. The N-terminal coiled-coil domains of Fer can autophosphorylate in trans, thereby regulating their cellular function through differential phosphorylation states. Growth factor exposure can induce tyrosine phosphorylation of Fer and recruitment of Fer to RTK complexes containing p85. It is expressed predominantly in mature hematopoietic cells of the granulocytic and monocytic lineage, and has been shown to be expressed in vascular endothelial cells. Fer is implicated in insulin signaling, cell-cell signaling, human prostatic proliferative diseases, and is involved in the regulation of G1 progression.

Research Areas: Cell Biology

Target Protein: FER

Applications: WB, IHC, ICC

Reactivity: Human, Mouse

Clonality: Monoclonal

Clone ID: 5D2C4

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: FER

Immunogen: Purified recombinant fragment of human FER expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 95kDa

UniProt Accession: P16591

Synonyms: TYK3, FER

GeneID: 2241

Research Use Only