FES Monoclonal Antibody - BT-MCA3864

FES Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3864-50, BT-MCA3864-100

Citations, Manuals and MSDS Available upon request.

Background: FES (feline sarcoma oncogene) and Fer are the only two members of a unique family of cytoplasmic protein tyrosine kinases. FES and Fer contain a central Src homology-2 (SH2) domain and a carboxy-terminal tyrosine kinase catalytic domain. They are structurally distinguished from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of amino-terminal Fer/CIP4 homology and coiled-coil domains. FES was originally identified as an oncogene from avian and feline retroviruses. Human c-Fes has been implicated in myeloid, vascular endothelial and neuronal cell differentiation. FES has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Mutations may activate the FES kinase and thereby contribute to cancer. However, recent data strongly suggests that the c-FES protein-tyrosine kinase is a tumor suppressor rather than a dominant oncogene in colorectal cancer.

Research Areas: Signal Transduction

Target Protein: FES

Applications: IHC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 2E3G3

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: FES

Immunogen: Purified recombinant fragment of FES (AA:613-822)expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: P07332

Synonyms: FPS

GeneID: 2242

Research Use Only