FGFR4 Monoclonal Antibody - BT-MCA3023

FGFR4 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3023-50, BT-MCA3023-100

Citations, Manuals and MSDS Available upon request.

Background: FGFR4: fibroblast growth factor receptor 4. Entrez Protein NP_002002. It is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.

Research Areas: Cardiovascular

Target Protein: FGFR4

Applications: ICC

Reactivity: Human

Clonality: Monoclonal

Clone ID: 7H1

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: FGFR4

Immunogen: Purified recombinant extracellular fragment of human FGFR4 fused with hIgGFc tag expressed in HEK293 cell line.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 87.9kDa

UniProt Accession: P22455

Synonyms: TKF, JTK2, CD334

GeneID: 2264

Research Use Only