Product Description

FGFR4 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66933-50, MB66933-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Fibroblast growth factors produce mitogenic and angiogenic effects in target cells by signaling through cell surface receptor tyrosine kinases. There are four members of the FGF receptor family: FGFR1, FGFR2 , FGFR3, and FGFR4. Each receptor contains an extracellμlar ligand-binding domain, a transmembrane domain, and a cytoplasmic kinase domain. Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues. Seven tyrosine residues in the cytoplasmic tail of FGFR1 can be phosphorylated: Tyr463, 583, 585, 653, 654, 730, and 766. Tyr653 and Tyr654 are important for catalytic activity of activated FGFR and are essential for signaling . The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components, such as Crk and PLC纬 .

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: JTK2, TKF, Fibroblast growth factor receptor 4, FGFR-4, CD334

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human FGFR4. The exact sequence is proprietary.

Dilution: WB (1/1000 - 1/2000)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of FGFR4 protein.

Molecular Weight: ~ 88 kDa

Pathway: Tumor Angiogenesis, ESC Pluripotency and Differentiation Signaling Pathway,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P22455

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only