Product Description

FGR Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3492-50, BT-MCA3492-100

Citations, Manuals and MSDS Available upon request.

Background: FGR: Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, also known as SRC2; c-fgr; c-src2; FLJ43153; MGC75096; p55c-fgr; p58c-fgr. It is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Research Areas: Signal Transduction

Target Protein: FGR

Applications: WB, IHC

Reactivity: Human, Mouse

Clonality: Monoclonal

Clone ID: 6G2

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: FGR

Immunogen: Purified recombinant fragment of human FGR expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 56kDa

UniProt Accession: P09769

Synonyms: SRC2, c-fgr, c-src2, p55c-fgr, p58c-fgr

GeneID: 2268

Research Use Only