Product Description

Fibrillarin Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB10920-50, MB10920-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: P22087

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB,IP

All Applications: WB: 1/500-1/1000 IP: 1/20

Background: Fibrillarin is a 2'-O-methyltransferase located in fibrillar regions and Cajal bodies of the nucleolus, where RNA transcription and pre-RNA processing take place. Fibrillarin associates with several other structual proteins as well as box C/D snoRNA to form a complex that functions in pre-rRNA processing, pre-rRNA methylation and ribosome assembly. This complex catalyzes site-specific 2'-O-ribose methylation of targeted nucleotides within the rRNA sequence. The sequence, structure and function of fibrillarin are highly conserved and fibrillarin gene expression is essential for early embryonic development.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Fibrillarin in K562, C6, 3T3Lysates using Fibrillarin antibody.

Bioworld Molecular Weight: Calculated MW: 34 kDa; Observed MW: 34 kDa

Specificity: IgG

Alternative Name: FIB; FLRN; Nop1; RNU3IP1

Immunogen: A synthetic peptide of human Fibrillarin

Conjugate: Unconjugated

Modification: Unmodified