Product Description

Fibronectin Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB65924-50, MB65924-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Fibronectin is a mμlti-domain extracellμlar matrix (ECM) protein. The protein uses its different domains to bind distinct ECM components such as collagens, growth factors, as well as cell surface integrins to carry on its functions. Fibronectin has been implicated in many essential biological processes including tissue repair, fibrosis, and tumor development. There are many fibronectin isoforms. Plasma fibronectin is synthesized by hepatocytes and exists as a compact, inactive conformation in the blood stream. It is a major component of fibrin clots. Upon binding to integrins or other cell surface receptors, fibronectin switches to an extended conformation, and exposes its function domains to activated extracellμlar matrix assembly. Fibroblast, endothelial cells, as well as many types of cancer cells have also been shown to synthesize cellμlar fibronectin isoforms. Among them, the EDA or EDB isoforms are particμlarly highly expressed during fibrosis and cancer development, and are potential diagnostic and therapeutic targets.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Mouse

Applications: WB, IHC, IF/ICC

Alternate Names: FN, Fibronectin, FN, Cold-insoluble globμlin, CIG

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence of human Fibronectin. The exact sequence is proprietary.

Dilution: WB (1/1000 - 1/2000), IHC (1/50 - 1/200), IF/ICC (1/50 - 1/200)

Purification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Recognizes endogenous levels of Fibronectin protein.

Molecular Weight: ~ 272 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P02751

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only