Product Description

Frizzled-6 (T167) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS5722-50, BS5722-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Frizzled-6 (FZD6, also known as frizzled homolog 6 in Drosophila) is a seven-transmembrane domain receptor that binds the Wnt ligand and influences macroscopic hair patterning and other tissue polarity events. Frizzled-6 protein contains a signal peptide and a cysteine-rich domain (CRD) in the N-terminal extracellμlar region, and does not contain a C-terminal PDZ domain-binding motif. Frizzled-3 and frizzled-6 influence neural tube closure and the planar orientation of hair bundles on a subset of auditory and vestibμlar sensory cells. Madin-Darby canine kidney (MDCK) cells are competent to form tubμles in vitro and express the frizzled-6 receptor, which is known to form a complex with Wnt-4 through the CRD in this cell type. Frizzled-6 is expressed as a 4.4 kb mRNA in various human tissues, including adμlt heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ICC, IP

Alternate Names: Frizzled6, Frizzled 6, Fz-6, hFz6, FZD6, FZD-6

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 167-212 of Human Frizzled-6.

Dilution: WB: 1:500~1:1000
ICC: 1:50~1:200
IP: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Frizzled-6 (T167) polyclonal antibody detects endogenous levels of Frizzled-6 protein.

Molecular Weight: ~ 79 kDa

Pathway: Wntβ catenin signaling，

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O60353

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only