Product Description

FRS3 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: ES2377-50, ES2377-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013],

Reactivity: Human, Monkey

Host: Rabbit

Applications: WB, ELISA

Alternate Names: FRS3, Fibroblast growth factor receptor substrate 3, FGFR substrate 3, FGFR-signaling adaptor SNT2, Suc1-associated neurotrophic factor target 2, SNT-2

Clonality: Polyclonal

Immunogen: The antiserum was produced against synthesized peptide derived from human FRS3. AA range:191-240

Isotype: IgG

Target: FRS3

Specificity: FRS3 Polyclonal Antibody detects endogenous levels of FRS3 protein.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml,

Formlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Expression: Brain, Placenta,

Observed Band (KD): 54kD

Function: Function: Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2
PTM: Phosphorylated on tyrosine residues upon stimulation by BFGF or NGFB
Similarity: Contains 1 IRS-type PTB domain
Subunit: Binds NTRK1 (By similarity). Binds FGFR1, NGFR, GRB2, PTPN11 and ERK2

Subcellular Location: Membrane, Lipid-anchor

Storage and Stability: -20°C/1 year

Gene Name: FRS3

Protein Name: Fibroblast growth factor receptor substrate 3

Mouse SwissProt Number: Q91WJ0

Research Use Only